Assay Detail
Binding
CHEMBL4054004
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Inhibition of Pseudomonas aeruginosa 6His-tagged GIM-1 (Q19 to D250 residues) expressed in Escherichia coli BL21 Star(DE3) pLysS using nitrocefin as substrate preincubated for 5 mins followed by substrate addition by spectrophotometric analysis
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pseudomonas aeruginosa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Metallo-β-lactamase inhibitors by bioisosteric replacement: Preparation, activity and binding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 4.88 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4089201 | — | — | 1 | 6.75 |
| CHEMBL4066078 | — | — | 1 | 6.51 |
| CHEMBL4104728 | — | — | 1 | 4.92 |
| CHEMBL4081245 | — | — | 1 | 4.89 |
| CHEMBL4061495 | — | — | 1 | 4.80 |
| CHEMBL4077556 | — | — | 1 | 4.75 |
| CHEMBL4090938 | — | — | 1 | 4.70 |
| CHEMBL4103833 | — | — | 1 | 4.64 |
| CHEMBL4095160 | — | — | 1 | 4.58 |
| CHEMBL4063031 | — | — | 1 | 4.58 |
| CHEMBL4079577 | — | — | 1 | 4.55 |
| CHEMBL4077011 | — | — | 1 | 4.44 |
| CHEMBL4102909 | — | — | 1 | 4.17 |
| CHEMBL4090030 | — | — | 1 | 4.00 |
| CHEMBL174367 | — | — | 1 | - |
| CHEMBL4087458 | — | — | 1 | - |
| CHEMBL4088285 | — | — | 1 | - |
| CHEMBL4105658 | — | — | 1 | - |
| CHEMBL4091349 | — | — | 1 | - |
| CHEMBL4075324 | — | — | 1 | - |
| CHEMBL4069211 | — | — | 1 | - |
| CHEMBL4075406 | — | — | 1 | - |
| CHEMBL4064978 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4089201 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4066078 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4104728 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4081245 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4061495 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL4077556 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4090938 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4103833 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL4095160 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL4063031 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL4079577 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL4077011 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL4102909 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL4090030 | — | IC50 | = | 99000.0 | nM | 4.00 |
| CHEMBL174367 | — | IC50 | - | — | - | |
| CHEMBL4087458 | — | IC50 | - | — | - | |
| CHEMBL4088285 | — | IC50 | = | 162000.0 | nM | - |
| CHEMBL4105658 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4091349 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4075324 | — | IC50 | = | 280000.0 | nM | - |
| CHEMBL4069211 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4075406 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4064978 | — | IC50 | = | 203000.0 | nM | - |