Assay Detail
Binding
CHEMBL4054024
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Inhibition of recombinant human MAO-A expressed in baculovirus infected BTI insect cell microsomes using kynuramine as substrate after 20 mins by fluorescence spectroscopy
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The evaluation of 1,4-benzoquinones as inhibitors of human monoamine oxidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.51 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL405110 | METHYLENE BLUE ANHYDROUS | 4.0 | 1 | 7.16 |
| CHEMBL18116 | TOLOXATONE | 4.0 | 1 | 5.41 |
| CHEMBL8320 | BENZOQUINONE | — | 1 | 5.32 |
| CHEMBL274117 | — | — | 1 | 5.30 |
| CHEMBL4100724 | — | — | 1 | 5.27 |
| CHEMBL4091051 | — | — | 1 | 5.23 |
| CHEMBL4101770 | — | — | 1 | 4.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL405110 | METHYLENE BLUE ANHYDROUS | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL18116 | TOLOXATONE | IC50 | = | 3920.0 | nM | 5.41 |
| CHEMBL8320 | BENZOQUINONE | IC50 | = | 4820.0 | nM | 5.32 |
| CHEMBL274117 | — | IC50 | = | 5030.0 | nM | 5.30 |
| CHEMBL4100724 | — | IC50 | = | 5370.0 | nM | 5.27 |
| CHEMBL4091051 | — | IC50 | = | 5840.0 | nM | 5.23 |
| CHEMBL4101770 | — | IC50 | = | 13200.0 | nM | 4.88 |