Assay Detail
ADMET
CHEMBL4054099
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human LO2 cells after 72 hrs by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | L02 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Scutellarin derivatives as apoptosis inducers: Design, synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.47 | 4.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4062766 | — | — | 1 | 4.71 |
| CHEMBL4079050 | — | — | 1 | 4.64 |
| CHEMBL4091087 | — | — | 1 | 4.49 |
| CHEMBL4077450 | — | — | 1 | 4.46 |
| CHEMBL4081307 | — | — | 1 | 4.40 |
| CHEMBL4084401 | — | — | 1 | 4.38 |
| CHEMBL4102367 | — | — | 1 | 4.34 |
| CHEMBL4068994 | — | — | 1 | 4.32 |
| CHEMBL4103309 | — | — | 1 | - |
| CHEMBL4086904 | — | — | 1 | - |
| CHEMBL4065473 | — | — | 1 | - |
| CHEMBL4059547 | — | — | 1 | - |
| CHEMBL487805 | SCUTELLARIN | — | 1 | - |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4062766 | — | IC50 | = | 19310.0 | nM | 4.71 |
| CHEMBL4079050 | — | IC50 | = | 22940.0 | nM | 4.64 |
| CHEMBL4091087 | — | IC50 | = | 32460.0 | nM | 4.49 |
| CHEMBL4077450 | — | IC50 | = | 34490.0 | nM | 4.46 |
| CHEMBL4081307 | — | IC50 | = | 39870.0 | nM | 4.40 |
| CHEMBL4084401 | — | IC50 | = | 41580.0 | nM | 4.38 |
| CHEMBL4102367 | — | IC50 | = | 45900.0 | nM | 4.34 |
| CHEMBL4068994 | — | IC50 | = | 47960.0 | nM | 4.32 |
| CHEMBL4103309 | — | IC50 | - | — | - | |
| CHEMBL4086904 | — | IC50 | - | — | - | |
| CHEMBL4065473 | — | IC50 | - | — | - | |
| CHEMBL4059547 | — | IC50 | - | — | - | |
| CHEMBL487805 | SCUTELLARIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL185 | FLUOROURACIL | IC50 | - | — | - |