Assay Detail
Binding
CHEMBL4054226
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of full-length mouse 11beta-HSD1 expressed in HEK293 microsomal fraction using [3H]cortisone as substrate after 1 hr by scintillation proximity assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
11-beta-hydroxysteroid dehydrogenase 1 (CHEMBL3910) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Synthesis of selective 11β-HSD1 inhibitors based on dammarane scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.62 | 8.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL230006 | ENOXOLONE | 2.0 | 1 | 8.13 |
| CHEMBL4102864 | — | — | 1 | 6.67 |
| CHEMBL4060927 | — | — | 1 | 6.40 |
| CHEMBL4084451 | — | — | 1 | 6.34 |
| CHEMBL4065535 | — | — | 1 | 6.32 |
| CHEMBL4102413 | — | — | 1 | 6.23 |
| CHEMBL4059599 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL230006 | ENOXOLONE | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL4102864 | — | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL4060927 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4084451 | — | IC50 | = | 454.0 | nM | 6.34 |
| CHEMBL4065535 | — | IC50 | = | 476.0 | nM | 6.32 |
| CHEMBL4102413 | — | IC50 | = | 592.0 | nM | 6.23 |
| CHEMBL4059599 | — | IC50 | = | 601.0 | nM | 6.22 |