Assay Detail
Functional
CHEMBL4054426
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Antiproliferative activity against human U373 cells after 72 hrs by MTT assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-373MG ATCC |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery and Characterization of R/S-N-3-Cyanophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea, a New Histone Deacetylase Class III Inhibitor Exerting Antiproliferative Activity against Cancer Cell Lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 4.69 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4084417 | — | — | 1 | 6.00 |
| CHEMBL4102380 | — | — | 1 | 5.22 |
| CHEMBL4094631 | — | — | 1 | 5.05 |
| CHEMBL4072725 | — | — | 1 | 5.00 |
| CHEMBL4092171 | — | — | 1 | 5.00 |
| CHEMBL4103408 | — | — | 1 | 4.92 |
| CHEMBL4074207 | — | — | 1 | 4.75 |
| CHEMBL4068289 | — | — | 1 | 4.70 |
| CHEMBL4094715 | — | — | 1 | 4.66 |
| CHEMBL4064472 | — | — | 1 | 4.66 |
| CHEMBL4064878 | — | — | 1 | 4.62 |
| CHEMBL4074109 | — | — | 1 | 4.52 |
| CHEMBL4095651 | — | — | 1 | 4.52 |
| CHEMBL4060881 | — | — | 1 | 4.48 |
| CHEMBL4094692 | — | — | 1 | 4.42 |
| CHEMBL380797 | SIRTINOL | — | 1 | 4.41 |
| CHEMBL4098102 | — | — | 1 | 4.35 |
| CHEMBL224864 | — | — | 1 | 4.32 |
| CHEMBL4080072 | — | — | 1 | 4.23 |
| CHEMBL4067934 | — | — | 1 | 4.01 |
| CHEMBL4077275 | — | — | 1 | - |
| CHEMBL4072915 | — | — | 1 | - |
| CHEMBL4099063 | — | — | 1 | - |
| CHEMBL4079157 | — | — | 1 | - |
| CHEMBL420311 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4084417 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4102380 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL4094631 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL4072725 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4092171 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4103408 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4074207 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4068289 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4094715 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL4064472 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL4064878 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL4074109 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL4095651 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL4060881 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL4094692 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL380797 | SIRTINOL | IC50 | = | 39300.0 | nM | 4.41 |
| CHEMBL4098102 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL224864 | — | IC50 | = | 47600.0 | nM | 4.32 |
| CHEMBL4080072 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL4067934 | — | IC50 | = | 97000.0 | nM | 4.01 |
| CHEMBL4077275 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4072915 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4099063 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4079157 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL420311 | — | IC50 | = | 157400.0 | nM | - |