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Assay Detail

CHEMBL4054643

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Non-competitive inhibition of human xanthine oxidase
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Xanthine dehydrogenase/oxidase (CHEMBL1929)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Xanthine oxidase inhibitors beyond allopurinol and febuxostat; an overview and selection of potential leads based on in silico calculated physico-chemical properties, predicted pharmacokinetics and toxicity.
Šmelcerović A, Tomović K, Šmelcerović Ž, Petronijević Ž, Kocić G, Tomašič T, Jakopin Ž, Anderluh M.
Eur J Med Chem (2017) 135 : 491 -516
PubMed 28478180 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 10.00 10.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1164729 FEBUXOSTAT 4.0 1 10.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1164729 FEBUXOSTAT Ki = 0.1 nM 10.00