Assay Detail
Binding
CHEMBL4054652
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of butter milk xanthine oxidase (unknown origin) assessed as reduction in uric acid formation using xanthine as substrate by spectrophotometric assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Not specified |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Xanthine oxidase inhibitors beyond allopurinol and febuxostat; an overview and selection of potential leads based on in silico calculated physico-chemical properties, predicted pharmacokinetics and toxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.33 | 7.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4087126 | — | — | 1 | 7.87 |
| CHEMBL4104972 | — | — | 1 | 7.04 |
| CHEMBL243664 | ACACETIN | — | 1 | 6.66 |
| CHEMBL2419923 | — | — | 1 | 6.46 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 6.42 |
| CHEMBL4084570 | — | — | 1 | 6.22 |
| CHEMBL4101522 | — | — | 1 | 5.70 |
| CHEMBL4062906 | — | — | 1 | 5.28 |
| CHEMBL1467 | ALLOPURINOL | 4.0 | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4087126 | — | IC50 | = | 13.6 | nM | 7.87 |
| CHEMBL4104972 | — | IC50 | = | 90.8 | nM | 7.04 |
| CHEMBL243664 | ACACETIN | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL2419923 | — | IC50 | = | 347.0 | nM | 6.46 |
| CHEMBL50 | QUERCETIN | IC50 | = | 383.0 | nM | 6.42 |
| CHEMBL4084570 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4101522 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4062906 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL1467 | ALLOPURINOL | IC50 | = | 5300.0 | nM | 5.28 |