Assay Detail
Binding
CHEMBL4054780
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Displacement of [3H]spiperone from human D4 receptor expressed in CHO cell membranes
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of molecular tools based on the dopamine D3 receptor ligand FAUC 329 showing inhibiting effects on drug and food maintained behavior.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.48 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2028019 | CARIPRAZINE | 4.0 | 1 | 6.96 |
| CHEMBL142020 | — | — | 1 | 6.82 |
| CHEMBL4064974 | — | — | 1 | 6.80 |
| CHEMBL4085920 | — | — | 1 | 5.33 |
| CHEMBL4060837 | — | — | 1 | - |
| CHEMBL4096858 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2028019 | CARIPRAZINE | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL142020 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL4064974 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL4085920 | — | Ki | = | 4700.0 | nM | 5.33 |
| CHEMBL4060837 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4096858 | — | Ki | > | 10000.0 | nM | - |