Assay Detail
Functional
CHEMBL4054800
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Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by SRB assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of novel benzylidene analogues of betulinic acid as potent cytotoxic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 5.50 | 5.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4088489 | — | — | 1 | 5.91 |
| CHEMBL4084656 | — | — | 1 | 5.82 |
| CHEMBL4094641 | — | — | 1 | 5.82 |
| CHEMBL4065179 | — | — | 1 | 5.77 |
| CHEMBL4064713 | — | — | 1 | 5.77 |
| CHEMBL4074122 | — | — | 1 | 5.75 |
| CHEMBL4092841 | — | — | 1 | 5.58 |
| CHEMBL4059567 | — | — | 1 | 5.55 |
| CHEMBL4059799 | — | — | 1 | 5.54 |
| CHEMBL4102597 | — | — | 1 | 5.52 |
| CHEMBL4060265 | — | — | 1 | 5.51 |
| CHEMBL4103041 | — | — | 1 | 5.51 |
| CHEMBL4073059 | — | — | 1 | 5.47 |
| CHEMBL4073769 | — | — | 1 | 5.47 |
| CHEMBL4084429 | — | — | 1 | 5.44 |
| CHEMBL4074845 | — | — | 1 | 5.41 |
| CHEMBL4085092 | — | — | 1 | 5.41 |
| CHEMBL4071114 | — | — | 1 | 5.40 |
| CHEMBL4062478 | — | — | 1 | 5.37 |
| CHEMBL4092410 | — | — | 1 | 5.33 |
| CHEMBL4087884 | — | — | 1 | 5.31 |
| CHEMBL4100578 | — | — | 1 | 5.29 |
| CHEMBL431525 | BETUNOLIC ACID | — | 1 | 5.24 |
| CHEMBL4095290 | — | — | 1 | 5.21 |
| CHEMBL4088073 | — | — | 1 | 5.11 |
| CHEMBL4068007 | — | — | 1 | - |
| CHEMBL4064485 | — | — | 1 | - |
| CHEMBL4090453 | — | — | 1 | - |
| CHEMBL269277 | BETULINIC ACID | 1.0 | 1 | - |
| CHEMBL4102386 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4088489 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL4084656 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4094641 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4065179 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4064713 | — | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL4074122 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4092841 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4059567 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4059799 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4102597 | — | IC50 | = | 3040.0 | nM | 5.52 |
| CHEMBL4060265 | — | IC50 | = | 3090.0 | nM | 5.51 |
| CHEMBL4103041 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4073059 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4073769 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4084429 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4074845 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4085092 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4071114 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4062478 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL4092410 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL4087884 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4100578 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL431525 | BETUNOLIC ACID | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4095290 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL4088073 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL4068007 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4064485 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4090453 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL269277 | BETULINIC ACID | IC50 | > | 10000.0 | nM | - |
| CHEMBL4102386 | — | IC50 | > | 10000.0 | nM | - |