Assay Detail
Functional
CHEMBL4055282
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MCF7 cells assessed as reduction in cell number after 48 hrs by MTT assay
19
Total Activities
10
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of nοvel artemisinin dimers with polyamine linkers and evaluation of their potential as anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.43 | 9.85 |
| Activity | 9 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | 3.0 | 2 | 9.85 |
| CHEMBL4067784 | — | — | 2 | 6.00 |
| CHEMBL4096693 | — | — | 2 | 6.00 |
| CHEMBL4078677 | — | — | 2 | 6.00 |
| CHEMBL4086522 | — | — | 2 | 6.00 |
| CHEMBL4092317 | — | — | 2 | 6.00 |
| CHEMBL4071531 | — | — | 2 | 6.00 |
| CHEMBL4082205 | — | — | 2 | 6.00 |
| CHEMBL4100214 | — | — | 2 | 6.00 |
| CHEMBL4104418 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | IC50 | = | 0.14 | nM | 9.85 |
| CHEMBL4067784 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4100214 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4082205 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4071531 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4092317 | — | IC50 | = | 999.0 | nM | 6.00 |
| CHEMBL4086522 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4078677 | — | IC50 | = | 999.0 | nM | 6.00 |
| CHEMBL4096693 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4100214 | — | Activity | - | — | - | |
| CHEMBL4082205 | — | Activity | - | — | - | |
| CHEMBL4071531 | — | Activity | - | — | - | |
| CHEMBL4092317 | — | Activity | - | — | - | |
| CHEMBL4086522 | — | Activity | - | — | - | |
| CHEMBL4078677 | — | Activity | - | — | - | |
| CHEMBL4096693 | — | Activity | - | — | - | |
| CHEMBL4067784 | — | Activity | - | — | - | |
| CHEMBL269671 | ARTEMISININ | Activity | - | — | - | |
| CHEMBL4104418 | — | IC50 | - | — | - |