Assay Detail
Binding
CHEMBL4055339
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5B SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addition after 1 hr by fluorescence polarization assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Signal transducer and activator of transcription 5B (CHEMBL5817) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Halogen-substituted catechol bisphosphates are potent and selective inhibitors of the transcription factor STAT5b.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.50 | 6.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4088092 | — | — | 1 | 6.81 |
| CHEMBL4104462 | — | — | 1 | 6.66 |
| CHEMBL4103576 | — | — | 1 | 6.63 |
| CHEMBL4085646 | — | — | 1 | 6.62 |
| CHEMBL4104019 | — | — | 1 | 6.58 |
| CHEMBL4080219 | — | — | 1 | 6.57 |
| CHEMBL4066274 | — | — | 1 | 6.55 |
| CHEMBL4086096 | — | — | 1 | 6.54 |
| CHEMBL4077592 | — | — | 1 | 6.48 |
| CHEMBL4093849 | — | — | 1 | 6.46 |
| CHEMBL4080740 | — | — | 1 | 6.41 |
| CHEMBL4075745 | — | — | 1 | 6.34 |
| CHEMBL4062751 | — | — | 1 | 6.21 |
| CHEMBL4076474 | — | — | 1 | 6.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4088092 | — | IC50 | = | 154.0 | nM | 6.81 |
| CHEMBL4104462 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4103576 | — | IC50 | = | 234.0 | nM | 6.63 |
| CHEMBL4085646 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4104019 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4080219 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4066274 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4086096 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4077592 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL4093849 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4080740 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL4075745 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL4062751 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL4076474 | — | IC50 | = | 660.0 | nM | 6.18 |