Assay Detail
Binding
CHEMBL4055662
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human renin
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of renin inhibitors guided by simulated annealing of chemical potential simulations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.04 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1639 | ALISKIREN | 4.0 | 1 | 9.22 |
| CHEMBL398584 | — | — | 1 | 9.00 |
| CHEMBL239496 | — | — | 1 | 8.15 |
| CHEMBL240355 | — | — | 1 | 7.70 |
| CHEMBL241663 | — | — | 1 | 7.32 |
| CHEMBL241458 | — | — | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1639 | ALISKIREN | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL398584 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL239496 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL240355 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL241663 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL241458 | — | IC50 | = | 141.0 | nM | 6.85 |