Assay Detail
Functional
CHEMBL4056534
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Growth inhibition of human H1299 cells incubated for 72 hrs by CCK8 assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1299 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a highly potent, selective and novel CDK9 inhibitor as an anticancer drug candidate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.83 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4078060 | — | — | 1 | 6.66 |
| CHEMBL2105717 | CABOZANTINIB | 4.0 | 1 | 5.72 |
| CHEMBL3545110 | RIBOCICLIB | 4.0 | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4078060 | — | IC50 | = | 221.0 | nM | 6.66 |
| CHEMBL2105717 | CABOZANTINIB | IC50 | = | 1919.0 | nM | 5.72 |
| CHEMBL3545110 | RIBOCICLIB | IC50 | = | 7637.0 | nM | 5.12 |