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Assay Detail

CHEMBL4056604

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to Aspergillus fumigatus CYP51
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Aspergillus fumigatus
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Lanosterol 14-alpha demethylase (CHEMBL3390824)
Type SINGLE PROTEIN
Organism Aspergillus

Publication

Design and optimization of highly-selective, broad spectrum fungal CYP51 inhibitors.
Yates CM, Garvey EP, Shaver SR, Schotzinger RJ, Hoekstra WJ.
Bioorg Med Chem Lett (2017) 27 : 3243 -3248
PubMed 28651982 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 1 7.89 7.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4077246 1 7.89

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4077246 Kd = 13.0 nM 7.89