Assay Detail
Binding
CHEMBL4056676
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Inhibition of HCK (75 to 526 residues) (unknown origin) expressed in Sf9 insect cells after 120 mins
11
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.97 | 9.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL45177 | — | — | 1 | 9.37 |
| CHEMBL4093003 | — | — | 2 | 7.96 |
| CHEMBL4085262 | — | — | 2 | 6.96 |
| CHEMBL4065334 | — | — | 2 | 6.68 |
| CHEMBL4103186 | — | — | 2 | 6.16 |
| CHEMBL4073943 | — | — | 2 | 5.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL45177 | — | IC50 | = | 0.4266 | nM | 9.37 |
| CHEMBL4093003 | — | IC50 | = | 10.96 | nM | 7.96 |
| CHEMBL4093003 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4085262 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL4085262 | — | IC50 | = | 112.2 | nM | 6.95 |
| CHEMBL4065334 | — | IC50 | = | 208.93 | nM | 6.68 |
| CHEMBL4065334 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4103186 | — | IC50 | = | 691.83 | nM | 6.16 |
| CHEMBL4103186 | — | IC50 | = | 686.0 | nM | 6.16 |
| CHEMBL4073943 | — | IC50 | = | 1318.26 | nM | 5.88 |
| CHEMBL4073943 | — | IC50 | = | 1323.0 | nM | 5.88 |