Assay Detail
Binding
CHEMBL4056785
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Trypanosoma brucei recombinant farnesyltransferase using dansyl peptide containing GCAIM as substrate in presence of farnesyl pyrophosphate after 15 mins by fluorescence assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma brucei |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-activity relationship studies on thiaplidiaquinones A and B as novel inhibitors of Plasmodium falciparum and farnesyltransferase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.02 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54044 | — | — | 1 | 8.00 |
| CHEMBL4066468 | — | — | 1 | 7.01 |
| CHEMBL4087793 | — | — | 1 | 6.66 |
| CHEMBL4076843 | — | — | 1 | 6.46 |
| CHEMBL4079913 | — | — | 1 | 6.13 |
| CHEMBL4086502 | — | — | 1 | 6.00 |
| CHEMBL4096919 | — | — | 1 | 5.80 |
| CHEMBL4098096 | — | — | 1 | 5.64 |
| CHEMBL4104673 | — | — | 1 | 5.54 |
| CHEMBL4104149 | — | — | 1 | 5.52 |
| CHEMBL4090877 | — | — | 1 | 5.48 |
| CHEMBL4105597 | — | — | 1 | 5.28 |
| CHEMBL4075066 | — | — | 1 | 4.71 |
| CHEMBL4075495 | — | — | 1 | - |
| CHEMBL4095500 | — | — | 1 | - |
| CHEMBL4063801 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54044 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4066468 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL4087793 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4076843 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4079913 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL4086502 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4096919 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4098096 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4104673 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4104149 | — | IC50 | = | 3040.0 | nM | 5.52 |
| CHEMBL4090877 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4105597 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL4075066 | — | IC50 | = | 19600.0 | nM | 4.71 |
| CHEMBL4075495 | — | IC50 | > | 22000.0 | nM | - |
| CHEMBL4095500 | — | IC50 | > | 22000.0 | nM | - |
| CHEMBL4063801 | — | IC50 | > | 22300.0 | nM | - |