Assay Detail
Functional
CHEMBL4056786
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Antiplasmodial activity against chloroquine-resistant erythrocyte stage of Plasmodium falciparum FcM29-Cameroon infected in human RBC assessed as reduction in [3H]hypoxanthine incorporation preincubated for 48 hrs followed by [3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationship studies on thiaplidiaquinones A and B as novel inhibitors of Plasmodium falciparum and farnesyltransferase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.68 | 6.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.35 |
| CHEMBL4066468 | — | — | 1 | 5.36 |
| CHEMBL4087793 | — | — | 1 | 5.34 |
| CHEMBL4079913 | — | — | 1 | - |
| CHEMBL4104149 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL4066468 | — | IC50 | = | 4390.0 | nM | 5.36 |
| CHEMBL4087793 | — | IC50 | = | 4560.0 | nM | 5.34 |
| CHEMBL4079913 | — | IC50 | > | 17000.0 | nM | - |
| CHEMBL4104149 | — | IC50 | > | 17000.0 | nM | - |