Assay Detail
Functional
CHEMBL4056787
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Antiplasmodial activity against chloroquine-sensitive IEF stage of Plasmodium falciparum NF54 infected in human RBC assessed as reduction in [3H]hypoxanthine incorporation preincubated for 48 hrs followed by [3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting method
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationship studies on thiaplidiaquinones A and B as novel inhibitors of Plasmodium falciparum and farnesyltransferase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.56 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 8.22 |
| CHEMBL4098096 | — | — | 1 | 6.54 |
| CHEMBL4075066 | — | — | 1 | 5.70 |
| CHEMBL4104673 | — | — | 1 | 5.54 |
| CHEMBL4086502 | — | — | 1 | 5.47 |
| CHEMBL4076843 | — | — | 1 | 5.40 |
| CHEMBL4075495 | — | — | 1 | 5.32 |
| CHEMBL4090877 | — | — | 1 | 5.14 |
| CHEMBL4105597 | — | — | 1 | 5.13 |
| CHEMBL4095500 | — | — | 1 | 5.10 |
| CHEMBL4063801 | — | — | 1 | 4.69 |
| CHEMBL4096919 | — | — | 1 | 4.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4098096 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4075066 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4104673 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4086502 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4076843 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4075495 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL4090877 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL4105597 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL4095500 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL4063801 | — | IC50 | = | 20400.0 | nM | 4.69 |
| CHEMBL4096919 | — | IC50 | = | 33900.0 | nM | 4.47 |