Assay Detail
Binding
CHEMBL4056903
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Inhibition of slow inactivated rat NaV1.7 at -20 mV holding potential after 5 mins by IonWorks electrophysiology method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium channel protein type 9 subunit alpha (CHEMBL3312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Discovery of a biarylamide series of potent, state-dependent NaV1.7 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.40 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4100514 | — | — | 1 | 7.64 |
| CHEMBL4076051 | — | — | 1 | 7.62 |
| CHEMBL4100413 | — | — | 1 | 7.37 |
| CHEMBL4071906 | — | — | 1 | 7.31 |
| CHEMBL4076380 | — | — | 1 | 7.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4100514 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4076051 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4100413 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL4071906 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL4076380 | — | IC50 | = | 88.0 | nM | 7.06 |