Assay Detail
Binding
CHEMBL4057013
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Inhibition of human dCTPase 1
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 1: Triazoles, triazolopyrimidines, triazinoindoles, quinoline hydrazones and arylpiperazines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 6.01 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4065181 | — | — | 1 | 7.70 |
| CHEMBL4075978 | — | — | 1 | 7.44 |
| CHEMBL3771105 | — | — | 1 | 7.33 |
| CHEMBL4075215 | — | — | 1 | 6.62 |
| CHEMBL4075933 | — | — | 1 | 6.44 |
| CHEMBL4096363 | — | — | 1 | 6.43 |
| CHEMBL1223844 | — | — | 1 | 6.28 |
| CHEMBL2359616 | — | — | 1 | 6.26 |
| CHEMBL4076147 | — | — | 1 | 6.21 |
| CHEMBL4062089 | — | — | 1 | 6.18 |
| CHEMBL4087792 | — | — | 1 | 6.11 |
| CHEMBL4081317 | — | — | 1 | 6.09 |
| CHEMBL1601571 | — | — | 1 | 6.08 |
| CHEMBL4077327 | — | — | 1 | 6.07 |
| CHEMBL4076346 | — | — | 1 | 6.07 |
| CHEMBL4105569 | — | — | 1 | 6.04 |
| CHEMBL1371330 | — | — | 1 | 6.03 |
| CHEMBL4060734 | — | — | 1 | 6.01 |
| CHEMBL4079182 | — | — | 1 | 6.00 |
| CHEMBL4074466 | — | — | 1 | 6.00 |
| CHEMBL4101233 | — | — | 1 | 6.00 |
| CHEMBL4062078 | — | — | 1 | 6.00 |
| CHEMBL1333280 | — | — | 1 | 5.96 |
| CHEMBL4067987 | — | — | 1 | 5.96 |
| CHEMBL4072835 | — | — | 1 | 5.96 |
| CHEMBL4074503 | — | — | 1 | 5.92 |
| CHEMBL1466802 | — | — | 1 | 5.92 |
| CHEMBL4065644 | — | — | 1 | 5.89 |
| CHEMBL1704017 | — | — | 1 | 5.85 |
| CHEMBL4089181 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4065181 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4075978 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL3771105 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL4075215 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4075933 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4096363 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL1223844 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL2359616 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL4076147 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL4062089 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL4087792 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL4081317 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL1601571 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL4077327 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL4076346 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL4105569 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL1371330 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL4060734 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL4062078 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4101233 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL4079182 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL4074466 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1333280 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4067987 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4072835 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4074503 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1466802 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4065644 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1704017 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4076368 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4079237 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4088119 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4089181 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4066852 | — | IC50 | = | 1910.0 | nM | 5.72 |
| CHEMBL4092548 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4103439 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL1728107 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4093494 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4098741 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL1535037 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4100287 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4071761 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL463763 | TRIPTOLIDE | IC50 | = | 30900.0 | nM | 4.51 |