Assay Detail
Binding
CHEMBL4057142
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Inhibition of Trypanosoma brucei rhodesiense rhodesain using Cbz-Phe-Arg-AMC as substrate measured for 10 mins by spectrofluorometric analysis
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Bistacrines as potential antitrypanosomal agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.83 | 5.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3814557 | — | — | 1 | 5.24 |
| CHEMBL73160 | — | — | 1 | 5.13 |
| CHEMBL3814548 | — | — | 1 | 4.88 |
| CHEMBL75274 | — | — | 1 | 4.77 |
| CHEMBL3815015 | — | — | 1 | 4.74 |
| CHEMBL424707 | — | — | 1 | 4.71 |
| CHEMBL3813885 | — | — | 1 | 4.58 |
| CHEMBL4103108 | — | — | 1 | 4.58 |
| CHEMBL179732 | — | — | 1 | - |
| CHEMBL73800 | — | — | 1 | - |
| CHEMBL32823 | — | — | 1 | - |
| CHEMBL4078832 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3814557 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL73160 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL3814548 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL75274 | — | IC50 | = | 16900.0 | nM | 4.77 |
| CHEMBL3815015 | — | IC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL424707 | — | IC50 | = | 19400.0 | nM | 4.71 |
| CHEMBL3813885 | — | IC50 | = | 26600.0 | nM | 4.58 |
| CHEMBL4103108 | — | IC50 | = | 26600.0 | nM | 4.58 |
| CHEMBL179732 | — | IC50 | - | — | - | |
| CHEMBL73800 | — | IC50 | - | — | - | |
| CHEMBL32823 | — | IC50 | - | — | - | |
| CHEMBL4078832 | — | IC50 | - | — | - |