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Assay Detail

CHEMBL4057154

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Competitive inhibition of Trypanosoma cruzi trypanothione reductase using varying levels of trypanothione disulfide as substrate by Lineweaver--burk plot analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Trypanosoma cruzi
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Trypanothione reductase (CHEMBL5131)
Type SINGLE PROTEIN
Organism Trypanosoma cruzi

Publication

Bistacrines as potential antitrypanosomal agents.
Schmidt I, Göllner S, Fuß A, Stich A, Kucharski A, Schirmeister T, Katzowitsch E, Bruhn H, Miliu A, Krauth-Siegel RL, Holzgrabe U.
Bioorg Med Chem (2017) 25 : 4526 -4531
PubMed 28698054 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 6.40 6.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL424707 1 6.40

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL424707 Ki = 400.0 nM 6.40