Assay Detail
Functional
CHEMBL4057174
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Inhibition of human recombinant BMP6-stimulated hepcidin mRNA expression in human HepG2 cells after 6 hrs by qRT-PCR analysis
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of DS79182026: A potent orally active hepcidin production inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 6.30 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4066592 | — | — | 1 | 7.41 |
| CHEMBL4088809 | — | — | 1 | 7.40 |
| CHEMBL4062692 | — | — | 1 | 7.38 |
| CHEMBL4061521 | — | — | 1 | 7.33 |
| CHEMBL4080212 | — | — | 1 | 7.16 |
| CHEMBL4077543 | — | — | 1 | 7.09 |
| CHEMBL4063674 | — | — | 1 | 6.89 |
| CHEMBL4067574 | — | — | 1 | 6.80 |
| CHEMBL4081873 | — | — | 1 | 6.68 |
| CHEMBL4064948 | — | — | 1 | 6.68 |
| CHEMBL4095072 | — | — | 1 | 6.64 |
| CHEMBL4076209 | — | — | 1 | 6.58 |
| CHEMBL4088455 | — | — | 1 | 6.54 |
| CHEMBL4084323 | — | — | 1 | 6.48 |
| CHEMBL4099876 | — | — | 1 | 6.46 |
| CHEMBL4074063 | — | — | 1 | 6.40 |
| CHEMBL260163 | — | — | 1 | 6.40 |
| CHEMBL4080955 | — | — | 1 | 6.34 |
| CHEMBL4094132 | — | — | 1 | 6.27 |
| CHEMBL4105203 | — | — | 1 | 6.24 |
| CHEMBL4092643 | — | — | 1 | 6.14 |
| CHEMBL4097501 | — | — | 1 | 6.04 |
| CHEMBL4103763 | — | — | 1 | 6.00 |
| CHEMBL4078504 | — | — | 1 | 5.96 |
| CHEMBL4096531 | — | — | 1 | 5.92 |
| CHEMBL4061027 | — | — | 1 | 5.85 |
| CHEMBL4084374 | — | — | 1 | 5.58 |
| CHEMBL4100824 | — | — | 1 | 5.58 |
| CHEMBL4067606 | — | — | 1 | 5.54 |
| CHEMBL4092127 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4066592 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4088809 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4062692 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4061521 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL4080212 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL4077543 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL4063674 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4067574 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4081873 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4064948 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4095072 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4076209 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4088455 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4084323 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL4099876 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4074063 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL260163 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4080955 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL4094132 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL4105203 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL4092643 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL4097501 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL4103763 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4078504 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4096531 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4061027 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4084374 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4100824 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4092127 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4067606 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4088833 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4071333 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL4072578 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL4104204 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4070324 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4080886 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4105124 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4070424 | — | IC50 | > | 3000.0 | nM | - |