Assay Detail
Binding
CHEMBL4057989
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Inhibition of COX2 (unknown origin) assessed as reduction in PGE2 level using arachidonic acid as substrate after 5 mins in presence of heme by ELISA
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of novel hybrids of pyrazole and coumarin as dual inhibitors of COX-2 and 5-LOX.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.21 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4082622 | — | — | 1 | 6.64 |
| CHEMBL4062197 | — | — | 1 | 6.54 |
| CHEMBL4070807 | — | — | 1 | 6.52 |
| CHEMBL4092434 | — | — | 1 | 6.48 |
| CHEMBL4075969 | — | — | 1 | 6.40 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 6.39 |
| CHEMBL4077653 | — | — | 1 | 6.37 |
| CHEMBL4077052 | — | — | 1 | 6.36 |
| CHEMBL4069891 | — | — | 1 | 6.31 |
| CHEMBL4101763 | — | — | 1 | 6.31 |
| CHEMBL4084887 | — | — | 1 | 6.31 |
| CHEMBL4102241 | — | — | 1 | 6.28 |
| CHEMBL4065986 | — | — | 1 | 6.27 |
| CHEMBL4076002 | — | — | 1 | 6.11 |
| CHEMBL4079043 | — | — | 1 | 6.11 |
| CHEMBL4076451 | — | — | 1 | 6.09 |
| CHEMBL4097207 | — | — | 1 | 6.07 |
| CHEMBL4069692 | — | — | 1 | 6.04 |
| CHEMBL4063233 | — | — | 1 | 5.84 |
| CHEMBL4065539 | — | — | 1 | 5.60 |
| CHEMBL4076889 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4082622 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4062197 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4070807 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4092434 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL4075969 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL118 | CELECOXIB | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL4077653 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4077052 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL4069891 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL4101763 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL4084887 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL4102241 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL4065986 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL4076002 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL4079043 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL4076451 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL4097207 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL4069692 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL4063233 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL4065539 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4076889 | — | IC50 | = | 3360.0 | nM | 5.47 |