Assay Detail
Functional
CHEMBL4057992
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Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of novel hybrids of pyrazole and coumarin as dual inhibitors of COX-2 and 5-LOX.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 4.92 | 5.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4097207 | — | — | 1 | 5.17 |
| CHEMBL4079043 | — | — | 1 | 5.14 |
| CHEMBL4063233 | — | — | 1 | 5.13 |
| CHEMBL4082622 | — | — | 1 | 5.07 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 5.07 |
| CHEMBL4069692 | — | — | 1 | 5.05 |
| CHEMBL4092434 | — | — | 1 | 5.02 |
| CHEMBL4076889 | — | — | 1 | 5.02 |
| CHEMBL4077052 | — | — | 1 | 4.95 |
| CHEMBL4076451 | — | — | 1 | 4.95 |
| CHEMBL4069891 | — | — | 1 | 4.94 |
| CHEMBL4102241 | — | — | 1 | 4.93 |
| CHEMBL4076002 | — | — | 1 | 4.93 |
| CHEMBL4075969 | — | — | 1 | 4.90 |
| CHEMBL4077653 | — | — | 1 | 4.89 |
| CHEMBL4084887 | — | — | 1 | 4.87 |
| CHEMBL4101763 | — | — | 1 | 4.79 |
| CHEMBL4065539 | — | — | 1 | 4.78 |
| CHEMBL4065986 | — | — | 1 | 4.76 |
| CHEMBL4070807 | — | — | 1 | 4.75 |
| CHEMBL4062197 | — | — | 1 | 4.75 |
| CHEMBL4087846 | — | — | 1 | 4.66 |
| CHEMBL51628 | UMBELLIFERONE | — | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4097207 | — | IC50 | = | 6820.0 | nM | 5.17 |
| CHEMBL4079043 | — | IC50 | = | 7290.0 | nM | 5.14 |
| CHEMBL4063233 | — | IC50 | = | 7430.0 | nM | 5.13 |
| CHEMBL4082622 | — | IC50 | = | 8460.0 | nM | 5.07 |
| CHEMBL118 | CELECOXIB | IC50 | = | 8470.0 | nM | 5.07 |
| CHEMBL4069692 | — | IC50 | = | 8850.0 | nM | 5.05 |
| CHEMBL4092434 | — | IC50 | = | 9610.0 | nM | 5.02 |
| CHEMBL4076889 | — | IC50 | = | 9640.0 | nM | 5.02 |
| CHEMBL4077052 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL4076451 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL4069891 | — | IC50 | = | 11370.0 | nM | 4.94 |
| CHEMBL4102241 | — | IC50 | = | 11730.0 | nM | 4.93 |
| CHEMBL4076002 | — | IC50 | = | 11760.0 | nM | 4.93 |
| CHEMBL4075969 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL4077653 | — | IC50 | = | 12990.0 | nM | 4.89 |
| CHEMBL4084887 | — | IC50 | = | 13660.0 | nM | 4.87 |
| CHEMBL4101763 | — | IC50 | = | 16040.0 | nM | 4.79 |
| CHEMBL4065539 | — | IC50 | = | 16760.0 | nM | 4.78 |
| CHEMBL4065986 | — | IC50 | = | 17270.0 | nM | 4.76 |
| CHEMBL4070807 | — | IC50 | = | 17830.0 | nM | 4.75 |
| CHEMBL4062197 | — | IC50 | = | 17600.0 | nM | 4.75 |
| CHEMBL4087846 | — | IC50 | = | 21980.0 | nM | 4.66 |
| CHEMBL51628 | UMBELLIFERONE | IC50 | = | 22670.0 | nM | 4.64 |