Assay Detail
Functional
CHEMBL4057994
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Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of novel hybrids of pyrazole and coumarin as dual inhibitors of COX-2 and 5-LOX.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 4.86 | 5.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4082622 | — | — | 1 | 5.35 |
| CHEMBL4092434 | — | — | 1 | 5.26 |
| CHEMBL4069891 | — | — | 1 | 5.14 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 5.12 |
| CHEMBL4077052 | — | — | 1 | 5.10 |
| CHEMBL4076002 | — | — | 1 | 5.08 |
| CHEMBL4077653 | — | — | 1 | 5.07 |
| CHEMBL4069692 | — | — | 1 | 5.03 |
| CHEMBL4065986 | — | — | 1 | 5.01 |
| CHEMBL4087846 | — | — | 1 | 4.84 |
| CHEMBL4065539 | — | — | 1 | 4.83 |
| CHEMBL4102241 | — | — | 1 | 4.82 |
| CHEMBL4084887 | — | — | 1 | 4.80 |
| CHEMBL4062197 | — | — | 1 | 4.80 |
| CHEMBL4097207 | — | — | 1 | 4.77 |
| CHEMBL4075969 | — | — | 1 | 4.72 |
| CHEMBL51628 | UMBELLIFERONE | — | 1 | 4.68 |
| CHEMBL4079043 | — | — | 1 | 4.66 |
| CHEMBL4070807 | — | — | 1 | 4.65 |
| CHEMBL4063233 | — | — | 1 | 4.59 |
| CHEMBL4076451 | — | — | 1 | 4.57 |
| CHEMBL4076889 | — | — | 1 | 4.54 |
| CHEMBL4101763 | — | — | 1 | 4.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4082622 | — | IC50 | = | 4480.0 | nM | 5.35 |
| CHEMBL4092434 | — | IC50 | = | 5520.0 | nM | 5.26 |
| CHEMBL4069891 | — | IC50 | = | 7310.0 | nM | 5.14 |
| CHEMBL118 | CELECOXIB | IC50 | = | 7680.0 | nM | 5.12 |
| CHEMBL4077052 | — | IC50 | = | 7940.0 | nM | 5.10 |
| CHEMBL4076002 | — | IC50 | = | 8420.0 | nM | 5.08 |
| CHEMBL4077653 | — | IC50 | = | 8450.0 | nM | 5.07 |
| CHEMBL4069692 | — | IC50 | = | 9280.0 | nM | 5.03 |
| CHEMBL4065986 | — | IC50 | = | 9720.0 | nM | 5.01 |
| CHEMBL4087846 | — | IC50 | = | 14310.0 | nM | 4.84 |
| CHEMBL4065539 | — | IC50 | = | 14670.0 | nM | 4.83 |
| CHEMBL4102241 | — | IC50 | = | 15210.0 | nM | 4.82 |
| CHEMBL4084887 | — | IC50 | = | 15830.0 | nM | 4.80 |
| CHEMBL4062197 | — | IC50 | = | 15650.0 | nM | 4.80 |
| CHEMBL4097207 | — | IC50 | = | 16840.0 | nM | 4.77 |
| CHEMBL4075969 | — | IC50 | = | 18830.0 | nM | 4.72 |
| CHEMBL51628 | UMBELLIFERONE | IC50 | = | 21110.0 | nM | 4.68 |
| CHEMBL4079043 | — | IC50 | = | 21950.0 | nM | 4.66 |
| CHEMBL4070807 | — | IC50 | = | 22540.0 | nM | 4.65 |
| CHEMBL4063233 | — | IC50 | = | 25780.0 | nM | 4.59 |
| CHEMBL4076451 | — | IC50 | = | 26960.0 | nM | 4.57 |
| CHEMBL4076889 | — | IC50 | = | 28500.0 | nM | 4.54 |
| CHEMBL4101763 | — | IC50 | = | 37660.0 | nM | 4.42 |