Assay Detail
Binding
CHEMBL4058247
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Binding affinity myocilin-OLF domain (unknown origin) by Sypro Orange dye-based DSF assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pocket detection and interaction-weighted ligand-similarity search yields novel high-affinity binders for Myocilin-OLF, a protein implicated in glaucoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 10 | 6.05 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL339587 | — | — | 1 | 7.00 |
| CHEMBL1432046 | — | — | 1 | 6.19 |
| CHEMBL1384068 | — | — | 1 | 4.96 |
| CHEMBL1597646 | — | — | 1 | - |
| CHEMBL1466906 | — | — | 1 | - |
| CHEMBL1814509 | — | — | 1 | - |
| CHEMBL1967666 | — | — | 1 | - |
| CHEMBL1594682 | — | — | 1 | - |
| CHEMBL4083833 | — | — | 1 | - |
| CHEMBL1979155 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL339587 | — | Kd | = | 99.0 | nM | 7.00 |
| CHEMBL1432046 | — | Kd | = | 650.0 | nM | 6.19 |
| CHEMBL1384068 | — | Kd | = | 11000.0 | nM | 4.96 |
| CHEMBL1597646 | — | Kd | = | 0.008 | nM | - |
| CHEMBL1466906 | — | Kd | = | 300000.0 | nM | - |
| CHEMBL1814509 | — | Kd | = | 220000.0 | nM | - |
| CHEMBL1967666 | — | Kd | = | 210000.0 | nM | - |
| CHEMBL1594682 | — | Kd | = | 200000.0 | nM | - |
| CHEMBL4083833 | — | Kd | = | 190000.0 | nM | - |
| CHEMBL1979155 | — | Kd | = | 170000.0 | nM | - |