Assay Detail
Binding
CHEMBL4058753
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse IDO-1 using tryptophan as substrate after 22 mins by LC-MS/MS method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.48 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4086143 | PF-06840003 | 1.0 | 1 | 5.82 |
| CHEMBL4061767 | — | — | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4086143 | PF-06840003 | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4061767 | — | IC50 | = | 7300.0 | nM | 5.14 |