Assay Detail
Functional
CHEMBL4059062
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 72 hrs by OZBlue assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Interfering with HuR-RNA Interaction: Design, Synthesis and Biological Characterization of Tanshinone Mimics as Novel, Effective HuR Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.66 | 5.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL227075 | DIHYDROTANSHINONE I | — | 1 | 5.43 |
| CHEMBL4064932 | — | — | 1 | 4.63 |
| CHEMBL4086397 | — | — | 1 | 4.54 |
| CHEMBL4075458 | — | — | 1 | 4.49 |
| CHEMBL4084798 | — | — | 1 | 4.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL227075 | DIHYDROTANSHINONE I | IC50 | = | 3730.0 | nM | 5.43 |
| CHEMBL4064932 | — | IC50 | = | 23490.0 | nM | 4.63 |
| CHEMBL4086397 | — | IC50 | = | 28670.0 | nM | 4.54 |
| CHEMBL4075458 | — | IC50 | = | 32690.0 | nM | 4.49 |
| CHEMBL4084798 | — | IC50 | = | 58520.0 | nM | 4.23 |