Assay Detail
Functional
CHEMBL4059063
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Cytotoxicity against human MDA-MB-231 cells assessed as decrease in cell viability after 72 hrs by OZBlue assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Interfering with HuR-RNA Interaction: Design, Synthesis and Biological Characterization of Tanshinone Mimics as Novel, Effective HuR Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.69 | 5.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL227075 | DIHYDROTANSHINONE I | — | 1 | 5.05 |
| CHEMBL4064932 | — | — | 1 | 4.84 |
| CHEMBL4075458 | — | — | 1 | 4.62 |
| CHEMBL4086397 | — | — | 1 | 4.62 |
| CHEMBL4084798 | — | — | 1 | 4.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL227075 | DIHYDROTANSHINONE I | IC50 | = | 8990.0 | nM | 5.05 |
| CHEMBL4064932 | — | IC50 | = | 14310.0 | nM | 4.84 |
| CHEMBL4075458 | — | IC50 | = | 24170.0 | nM | 4.62 |
| CHEMBL4086397 | — | IC50 | = | 23790.0 | nM | 4.62 |
| CHEMBL4084798 | — | IC50 | = | 47180.0 | nM | 4.33 |