Assay Detail
Binding
CHEMBL4059396
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Inhibition of human N-terminal MBP-fused NEU2 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition measured every minute for 30 mins by fluorescence based assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective Inhibitors of Human Neuraminidase 3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 4.73 | 5.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 5.24 |
| CHEMBL4099818 | — | — | 1 | 4.77 |
| CHEMBL96712 | NEU5AC2EN | — | 1 | 4.60 |
| CHEMBL4076203 | — | — | 1 | 4.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222813 | ZANAMIVIR | Ki | = | 5700.0 | nM | 5.24 |
| CHEMBL4099818 | — | Ki | = | 17000.0 | nM | 4.77 |
| CHEMBL96712 | NEU5AC2EN | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL4076203 | — | Ki | = | 48000.0 | nM | 4.32 |