Assay Detail
Binding
CHEMBL4059435
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to dog N-terminal GST-tagged GRP94 N41 deletion mutant (69 to 337 residues) expressed in Escherichia coli BL21star (DE3) at 298 K by ITC assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure Based Design of a Grp94-Selective Inhibitor: Exploiting a Key Residue in Grp94 To Optimize Paralog-Selective Binding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 6.44 | 8.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL414883 | RADICICOL | — | 1 | 8.32 |
| CHEMBL4075556 | — | — | 1 | 6.19 |
| CHEMBL3426787 | — | — | 1 | 5.86 |
| CHEMBL4098757 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL414883 | RADICICOL | Kd | = | 4.8 | nM | 8.32 |
| CHEMBL4075556 | — | Kd | = | 650.0 | nM | 6.19 |
| CHEMBL3426787 | — | Kd | = | 1380.0 | nM | 5.86 |
| CHEMBL4098757 | — | Kd | = | 4000.0 | nM | 5.40 |