Assay Detail
Functional
CHEMBL4118532
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Antiproliferative activity against human SW620 cells harboring KRAS G12V mutant after 72 hrs by CellTiter-Glo assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW-620 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Studies of TAK1-centered polypharmacology with novel covalent TAK1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.43 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1614701 | SELUMETINIB | 4.0 | 1 | 7.82 |
| CHEMBL3883384 | — | — | 1 | 7.17 |
| CHEMBL3884293 | — | — | 1 | 6.61 |
| CHEMBL3884839 | — | — | 1 | 6.30 |
| CHEMBL3590106 | ULIXERTINIB | 2.0 | 1 | 6.30 |
| CHEMBL3884614 | — | — | 1 | 6.15 |
| CHEMBL3884960 | — | — | 1 | 6.12 |
| CHEMBL4127488 | — | — | 1 | 5.78 |
| CHEMBL1077979 | — | — | 1 | 5.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3883384 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL3884293 | — | IC50 | = | 247.0 | nM | 6.61 |
| CHEMBL3884839 | — | IC50 | = | 506.0 | nM | 6.30 |
| CHEMBL3590106 | ULIXERTINIB | IC50 | = | 499.0 | nM | 6.30 |
| CHEMBL3884614 | — | IC50 | = | 707.0 | nM | 6.15 |
| CHEMBL3884960 | — | IC50 | = | 767.0 | nM | 6.12 |
| CHEMBL4127488 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL1077979 | — | IC50 | = | 2540.0 | nM | 5.59 |