Assay Detail
Functional
CHEMBL4118536
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Antiproliferative activity against human SW156 cells harboring wild type KRAS after 72 hrs by CellTiter-Glo assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Studies of TAK1-centered polypharmacology with novel covalent TAK1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.95 | 7.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3883384 | — | — | 1 | 7.08 |
| CHEMBL3884293 | — | — | 1 | 6.44 |
| CHEMBL3590106 | ULIXERTINIB | 2.0 | 1 | 5.91 |
| CHEMBL1077979 | — | — | 1 | 5.70 |
| CHEMBL3884960 | — | — | 1 | 5.54 |
| CHEMBL3884839 | — | — | 1 | 5.52 |
| CHEMBL3884614 | — | — | 1 | 5.43 |
| CHEMBL4127488 | — | — | 1 | - |
| CHEMBL1614701 | SELUMETINIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3883384 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL3884293 | — | IC50 | = | 363.0 | nM | 6.44 |
| CHEMBL3590106 | ULIXERTINIB | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL1077979 | — | IC50 | = | 2020.0 | nM | 5.70 |
| CHEMBL3884960 | — | IC50 | = | 2880.0 | nM | 5.54 |
| CHEMBL3884839 | — | IC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL3884614 | — | IC50 | = | 3730.0 | nM | 5.43 |
| CHEMBL4127488 | — | IC50 | > | 1.0 | 10'-4nM | - |
| CHEMBL1614701 | SELUMETINIB | IC50 | > | 1.0 | 10'-4nM | - |