Assay Detail
Functional
CHEMBL4119114
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human SKOV3 cells assessed as reduction in cell viability after 5 days by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-OV-3 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Preussilides A-F, Bicyclic Polyketides from the Endophytic Fungus Preussia similis with Antiproliferative Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.64 | 10.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 10.63 |
| CHEMBL4126187 | — | — | 1 | 4.81 |
| CHEMBL4127726 | — | — | 1 | 4.70 |
| CHEMBL4127416 | — | — | 1 | 4.65 |
| CHEMBL4129629 | — | — | 1 | 4.54 |
| CHEMBL4128814 | — | — | 1 | 4.49 |
| CHEMBL4126336 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.0236 | nM | 10.63 |
| CHEMBL4126187 | — | IC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL4127726 | — | IC50 | = | 20190.0 | nM | 4.70 |
| CHEMBL4127416 | — | IC50 | = | 22600.0 | nM | 4.65 |
| CHEMBL4129629 | — | IC50 | = | 29100.0 | nM | 4.54 |
| CHEMBL4128814 | — | IC50 | = | 32400.0 | nM | 4.49 |
| CHEMBL4126336 | — | IC50 | > | 2437500.0 | nM | - |