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Assay Detail

CHEMBL4119399

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Binding
Inhibition of yeast alpha-glucosidase using p-nitrophenyl-alpha-glucopyranoside as substrate measured after 30 mins
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Saccharomyces cerevisiae
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Chemoenzymatic Synthesis and α-Glucosidase Inhibitory Activity of Dimeric Neolignans Inspired by Magnolol.
Pulvirenti L, Muccilli V, Cardullo N, Spatafora C, Tringali C.
J Nat Prod (2017) 80 : 1648 -1657
PubMed 28497968 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.73 6.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4130074 1 6.82
CHEMBL4127893 1 6.31
CHEMBL1958308 1 6.30
CHEMBL4129640 1 6.07
CHEMBL4127465 1 5.96
CHEMBL180920 MAGNOLOL 1 5.70
CHEMBL182629 1 5.70
CHEMBL181201 1 5.68
CHEMBL4128706 1 5.54
CHEMBL4127603 1 5.48
CHEMBL4128855 1 5.39
CHEMBL50 QUERCETIN 3.0 1 4.85
CHEMBL16901 HONOKIOL 1 4.64
CHEMBL4126230 1 -
CHEMBL4126352 1 -
CHEMBL404271 ACARBOSE 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4130074 IC50 = 150.0 nM 6.82
CHEMBL4127893 IC50 = 490.0 nM 6.31
CHEMBL1958308 IC50 = 500.0 nM 6.30
CHEMBL4129640 IC50 = 860.0 nM 6.07
CHEMBL4127465 IC50 = 1100.0 nM 5.96
CHEMBL180920 MAGNOLOL IC50 = 2000.0 nM 5.70
CHEMBL182629 IC50 = 2000.0 nM 5.70
CHEMBL181201 IC50 = 2100.0 nM 5.68
CHEMBL4128706 IC50 = 2900.0 nM 5.54
CHEMBL4127603 IC50 = 3300.0 nM 5.48
CHEMBL4128855 IC50 = 4100.0 nM 5.39
CHEMBL50 QUERCETIN IC50 = 14200.0 nM 4.85
CHEMBL16901 HONOKIOL IC50 = 23000.0 nM 4.64
CHEMBL4126230 IC50 > 100000.0 nM -
CHEMBL4126352 IC50 > 100000.0 nM -
CHEMBL404271 ACARBOSE IC50 = 269900.0 nM -