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Assay Detail

CHEMBL4119456

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MDA-MB-231
Confidence 1 — Organism
Curated By Intermediate

Target

MDA-MB-231 (CHEMBL400)
Type CELL-LINE
Organism Homo sapiens

Publication

Novel NO-releasing plumbagin derivatives: Design, synthesis and evaluation of antiproliferative activity.
Bao N, Ou J, Xu M, Guan F, Shi W, Sun J, Chen L.
Eur J Med Chem (2017) 137 : 88 -95
PubMed 28558333 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 5.66 6.47

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL64130 NAPABUCASIN 3.0 1 6.47
CHEMBL4126770 1 5.92
CHEMBL4130178 1 5.91
CHEMBL4129383 1 5.82
CHEMBL4126990 1 5.82
CHEMBL4125932 1 5.75
CHEMBL4126940 1 5.70
CHEMBL4127997 1 5.68
CHEMBL4129915 1 5.62
CHEMBL4126913 1 5.57
CHEMBL4129245 1 5.49
CHEMBL4128146 1 5.37
CHEMBL4128001 1 5.28
CHEMBL295316 PLUMBAGIN 1.0 1 4.85

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL64130 NAPABUCASIN IC50 = 340.0 nM 6.47
CHEMBL4126770 IC50 = 1210.0 nM 5.92
CHEMBL4130178 IC50 = 1240.0 nM 5.91
CHEMBL4129383 IC50 = 1510.0 nM 5.82
CHEMBL4126990 IC50 = 1520.0 nM 5.82
CHEMBL4125932 IC50 = 1760.0 nM 5.75
CHEMBL4126940 IC50 = 1980.0 nM 5.70
CHEMBL4127997 IC50 = 2110.0 nM 5.68
CHEMBL4129915 IC50 = 2420.0 nM 5.62
CHEMBL4126913 IC50 = 2670.0 nM 5.57
CHEMBL4129245 IC50 = 3270.0 nM 5.49
CHEMBL4128146 IC50 = 4310.0 nM 5.37
CHEMBL4128001 IC50 = 5200.0 nM 5.28
CHEMBL295316 PLUMBAGIN IC50 = 14230.0 nM 4.85