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Assay Detail

CHEMBL4119645

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against human RWPE1 cells assessed as reduction in cell viability after 48 hrs by MTT assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type RWPE-1
Confidence 1 — Organism
Curated By Intermediate

Target

RWPE-1 (CHEMBL4296492)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis of thiazole linked indolyl-3-glyoxylamide derivatives as tubulin polymerization inhibitors.
Guggilapu SD, Guntuku L, Reddy TS, Nagarsenkar A, Sigalapalli DK, Naidu VGM, Bhargava SK, Bathini NB.
Eur J Med Chem (2017) 138 : 83 -95
PubMed 28648953 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 6.15 6.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4126148 1 6.15

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4126148 IC50 = 710.0 nM 6.15