Assay Detail
Functional
CHEMBL4119718
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against Ptch+/- and p53-/- mouse medulloblastoma cells after 36 hrs by Brdu incorporation assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Medulloblastoma cell |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, and biological evaluation of optimized phthalazine derivatives as hedgehog signaling pathway inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.55 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4125930 | — | — | 1 | 7.70 |
| CHEMBL4127309 | — | — | 1 | 7.61 |
| CHEMBL473417 | VISMODEGIB | 4.0 | 1 | 7.52 |
| CHEMBL2142592 | TALADEGIB | 2.0 | 1 | 7.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4125930 | — | IC50 | = | 20.1 | nM | 7.70 |
| CHEMBL4127309 | — | IC50 | = | 24.6 | nM | 7.61 |
| CHEMBL473417 | VISMODEGIB | IC50 | = | 30.4 | nM | 7.52 |
| CHEMBL2142592 | TALADEGIB | IC50 | = | 43.5 | nM | 7.36 |