Assay Detail
Binding
CHEMBL4119773
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant 6His-tagged USP7 using Ub-Rh110 as substrate preincubated for 30 mins followed by substrate addition measured after 180 mins by fluorometric analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Ubiquitin carboxyl-terminal hydrolase 7 (CHEMBL2157850) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Chemical Approaches to Intervening in Ubiquitin Specific Protease 7 (USP7) Function for Oncology and Immune Oncology Therapies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.44 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL510492 | XESTOQUINONE | — | 1 | 6.89 |
| CHEMBL4128416 | — | — | 1 | 6.31 |
| CHEMBL4126079 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL510492 | XESTOQUINONE | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4128416 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL4126079 | — | IC50 | = | 750.0 | nM | 6.12 |