Assay Detail
Binding
CHEMBL4119782
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Binding affinity to wild-type human PIK3Cdelta (R108 to Q1044 residues) expressed in mammalian expression system by KINOMEScan assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (CHEMBL3130) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Potential of PI3Kβ Inhibitors in the Treatment of Cancer and Other Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 11 | 6.58 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4125781 | — | — | 1 | 8.15 |
| CHEMBL4130282 | — | — | 1 | 7.82 |
| CHEMBL4128507 | — | — | 1 | 7.24 |
| CHEMBL4127425 | — | — | 1 | 7.17 |
| CHEMBL4127116 | — | — | 1 | 6.99 |
| CHEMBL4129062 | — | — | 1 | 6.93 |
| CHEMBL4127822 | — | — | 1 | 6.49 |
| CHEMBL4127570 | — | — | 1 | 6.49 |
| CHEMBL4128821 | — | — | 1 | 5.27 |
| CHEMBL4129223 | — | — | 1 | 4.99 |
| CHEMBL4127012 | — | — | 1 | 4.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4125781 | — | Kd | = | 7.0 | nM | 8.15 |
| CHEMBL4130282 | — | Kd | = | 15.0 | nM | 7.82 |
| CHEMBL4128507 | — | Kd | = | 57.0 | nM | 7.24 |
| CHEMBL4127425 | — | Kd | = | 68.0 | nM | 7.17 |
| CHEMBL4127116 | — | Kd | = | 102.0 | nM | 6.99 |
| CHEMBL4129062 | — | Kd | = | 117.0 | nM | 6.93 |
| CHEMBL4127822 | — | Kd | = | 324.0 | nM | 6.49 |
| CHEMBL4127570 | — | Kd | = | 324.0 | nM | 6.49 |
| CHEMBL4128821 | — | Kd | = | 5370.0 | nM | 5.27 |
| CHEMBL4129223 | — | Kd | = | 10192.0 | nM | 4.99 |
| CHEMBL4127012 | — | Kd | = | 16407.0 | nM | 4.79 |