Assay Detail
Binding
CHEMBL4119783
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Binding affinity to wild-type human PIK3Cgamma (S144 to A1102 residues) expressed in mammalian expression system by KINOMEScan assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (CHEMBL3267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Potential of PI3Kβ Inhibitors in the Treatment of Cancer and Other Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 11 | 5.81 | 6.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4125781 | — | — | 1 | 6.67 |
| CHEMBL4130282 | — | — | 1 | 6.50 |
| CHEMBL4128507 | — | — | 1 | 6.00 |
| CHEMBL4129062 | — | — | 1 | 5.88 |
| CHEMBL4127116 | — | — | 1 | 5.76 |
| CHEMBL4127425 | — | — | 1 | 5.74 |
| CHEMBL4129223 | — | — | 1 | 5.54 |
| CHEMBL4127822 | — | — | 1 | 5.47 |
| CHEMBL4128821 | — | — | 1 | 5.37 |
| CHEMBL4127570 | — | — | 1 | 5.18 |
| CHEMBL4127012 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4125781 | — | Kd | = | 214.0 | nM | 6.67 |
| CHEMBL4130282 | — | Kd | = | 313.0 | nM | 6.50 |
| CHEMBL4128507 | — | Kd | = | 994.0 | nM | 6.00 |
| CHEMBL4129062 | — | Kd | = | 1318.0 | nM | 5.88 |
| CHEMBL4127116 | — | Kd | = | 1738.0 | nM | 5.76 |
| CHEMBL4127425 | — | Kd | = | 1820.0 | nM | 5.74 |
| CHEMBL4129223 | — | Kd | = | 2851.0 | nM | 5.54 |
| CHEMBL4127822 | — | Kd | = | 3412.0 | nM | 5.47 |
| CHEMBL4128821 | — | Kd | = | 4266.0 | nM | 5.37 |
| CHEMBL4127570 | — | Kd | = | 6607.0 | nM | 5.18 |
| CHEMBL4127012 | — | Kd | > | 30200.0 | nM | - |