Assay Detail
Binding
CHEMBL4119784
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to wild-type human MTOR (L1382 to W2549 residues) expressed in mammalian expression system by KINOMEScan assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase mTOR (CHEMBL2842) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Potential of PI3Kβ Inhibitors in the Treatment of Cancer and Other Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 11 | 4.68 | 4.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4127822 | — | — | 1 | 4.77 |
| CHEMBL4127570 | — | — | 1 | 4.75 |
| CHEMBL4128507 | — | — | 1 | 4.72 |
| CHEMBL4127425 | — | — | 1 | 4.63 |
| CHEMBL4130282 | — | — | 1 | 4.55 |
| CHEMBL4127012 | — | — | 1 | - |
| CHEMBL4129062 | — | — | 1 | - |
| CHEMBL4125781 | — | — | 1 | - |
| CHEMBL4129223 | — | — | 1 | - |
| CHEMBL4127116 | — | — | 1 | - |
| CHEMBL4128821 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4127822 | — | Kd | = | 17128.0 | nM | 4.77 |
| CHEMBL4127570 | — | Kd | = | 17783.0 | nM | 4.75 |
| CHEMBL4128507 | — | Kd | = | 18905.0 | nM | 4.72 |
| CHEMBL4127425 | — | Kd | = | 23442.0 | nM | 4.63 |
| CHEMBL4130282 | — | Kd | = | 28184.0 | nM | 4.55 |
| CHEMBL4127012 | — | Kd | > | 30200.0 | nM | - |
| CHEMBL4129062 | — | Kd | > | 30200.0 | nM | - |
| CHEMBL4125781 | — | Kd | > | 30200.0 | nM | - |
| CHEMBL4129223 | — | Kd | > | 30200.0 | nM | - |
| CHEMBL4127116 | — | Kd | > | 30200.0 | nM | - |
| CHEMBL4128821 | — | Kd | > | 30200.0 | nM | - |