Assay Detail
Binding
CHEMBL4119876
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of DLK in CD-1 mouse DRG neuron assessed as axonal protection pre-incubated for 2 hrs before NGF deprivation for 16 to 20 hrs by Campenot chamber based fluorescence assay
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Mitogen-activated protein kinase kinase kinase 12 (CHEMBL4295854) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.29 | 6.34 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3715238 | — | — | 2 | 6.34 |
| CHEMBL3719135 | — | — | 2 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3715238 | — | EC50 | = | 457.0 | nM | 6.34 |
| CHEMBL3719135 | — | EC50 | = | 574.0 | nM | 6.24 |
| CHEMBL3719135 | — | Activity | - | — | - | |
| CHEMBL3715238 | — | Activity | - | — | - |