Assay Detail
Binding
CHEMBL4120967
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Inhibition of Influenza A virus (A/Mississippi/03/01 (H1N1)) neuraminidase H274Y mutant using 4-MUNANA as substrate preincubated for 60 mins followed by substrate addition measured every min for 60 mins by fluorescence assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Structural and Functional Analysis of Anti-Influenza Activity of 4-, 7-, 8- and 9-Deoxygenated 2,3-Difluoro- N-acetylneuraminic Acid Derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.89 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 8.66 |
| CHEMBL4127125 | — | — | 1 | 6.98 |
| CHEMBL4128362 | — | — | 1 | 6.94 |
| CHEMBL4126987 | — | — | 1 | 6.88 |
| CHEMBL4125754 | — | — | 1 | 6.55 |
| CHEMBL4125895 | — | — | 1 | 5.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222813 | ZANAMIVIR | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL4127125 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL4128362 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL4126987 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL4125754 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4125895 | — | IC50 | = | 4690.0 | nM | 5.33 |