Assay Detail
Binding
CHEMBL4120970
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Influenza A virus (A/swine/Shepparton/6/2009 (H1N1)) neuraminidase activity using 4-MUNANA as substrate measured every min for 60 mins by fluorescence assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Structural and Functional Analysis of Anti-Influenza Activity of 4-, 7-, 8- and 9-Deoxygenated 2,3-Difluoro- N-acetylneuraminic Acid Derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.03 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 8.24 |
| CHEMBL4127125 | — | — | 1 | 6.38 |
| CHEMBL4126987 | — | — | 1 | 6.32 |
| CHEMBL4128362 | — | — | 1 | 6.10 |
| CHEMBL4125754 | — | — | 1 | 4.59 |
| CHEMBL4125895 | — | — | 1 | 4.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222813 | ZANAMIVIR | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL4127125 | — | IC50 | = | 418.0 | nM | 6.38 |
| CHEMBL4126987 | — | IC50 | = | 474.0 | nM | 6.32 |
| CHEMBL4128362 | — | IC50 | = | 791.0 | nM | 6.10 |
| CHEMBL4125754 | — | IC50 | = | 25770.0 | nM | 4.59 |
| CHEMBL4125895 | — | IC50 | = | 29640.0 | nM | 4.53 |