Assay Detail
Binding
CHEMBL4120975
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Inhibition of Influenza A virus (A/chicken/Bangli/BBVD-563/2007(H5N1)) clade 2 neuraminidase activity using 4-MUNANA as substrate measured every min for 60 mins by fluorescence assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus (A/chicken/Bangli/BBVD-563/2007(H5N1)) |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Structural and Functional Analysis of Anti-Influenza Activity of 4-, 7-, 8- and 9-Deoxygenated 2,3-Difluoro- N-acetylneuraminic Acid Derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.00 | 7.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 7.95 |
| CHEMBL4127125 | — | — | 1 | 6.55 |
| CHEMBL4126987 | — | — | 1 | 6.27 |
| CHEMBL4128362 | — | — | 1 | 6.05 |
| CHEMBL4125895 | — | — | 1 | 4.62 |
| CHEMBL4125754 | — | — | 1 | 4.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222813 | ZANAMIVIR | IC50 | = | 11.2 | nM | 7.95 |
| CHEMBL4127125 | — | IC50 | = | 281.0 | nM | 6.55 |
| CHEMBL4126987 | — | IC50 | = | 535.0 | nM | 6.27 |
| CHEMBL4128362 | — | IC50 | = | 889.0 | nM | 6.05 |
| CHEMBL4125895 | — | IC50 | = | 23770.0 | nM | 4.62 |
| CHEMBL4125754 | — | IC50 | = | 28200.0 | nM | 4.55 |