Assay Detail
Binding
CHEMBL4120977
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Inhibition of Influenza A virus (A/Fukui/45/04(H3N2)) neuraminidase activity using 4-MUNANA as substrate preincubated for 60 mins followed by substrate addition measured every min for 60 mins by fluorescence assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus (A/Fukui/45/2004(H3N2)) |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Neuraminidase (CHEMBL6015) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza A virus (A/Memphis/1/1971(H3N2)) |
Publication
Structural and Functional Analysis of Anti-Influenza Activity of 4-, 7-, 8- and 9-Deoxygenated 2,3-Difluoro- N-acetylneuraminic Acid Derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.18 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 8.42 |
| CHEMBL4126987 | — | — | 1 | 6.50 |
| CHEMBL4127125 | — | — | 1 | 6.46 |
| CHEMBL4128362 | — | — | 1 | 5.86 |
| CHEMBL4125754 | — | — | 1 | 5.30 |
| CHEMBL4125895 | — | — | 1 | 4.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222813 | ZANAMIVIR | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL4126987 | — | IC50 | = | 318.0 | nM | 6.50 |
| CHEMBL4127125 | — | IC50 | = | 345.0 | nM | 6.46 |
| CHEMBL4128362 | — | IC50 | = | 1377.0 | nM | 5.86 |
| CHEMBL4125754 | — | IC50 | = | 5010.0 | nM | 5.30 |
| CHEMBL4125895 | — | IC50 | = | 29510.0 | nM | 4.53 |