Assay Detail
Binding
CHEMBL4120983
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Inhibition of Influenza B virus (B/Perth/211/2001) neuraminidase D197E mutant activity using 4-MUNANA as substrate preincubated for 60 mins followed by substrate addition measured every min for 60 mins by fluorescence assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza B virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Neuraminidase (CHEMBL3377) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza B virus (strain B/Lee/1940) |
Publication
Structural and Functional Analysis of Anti-Influenza Activity of 4-, 7-, 8- and 9-Deoxygenated 2,3-Difluoro- N-acetylneuraminic Acid Derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.14 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4126987 | — | — | 1 | 7.50 |
| CHEMBL4128362 | — | — | 1 | 6.76 |
| CHEMBL4127125 | — | — | 1 | 6.67 |
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 6.59 |
| CHEMBL4125754 | — | — | 1 | 4.84 |
| CHEMBL4125895 | — | — | 1 | 4.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4126987 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4128362 | — | IC50 | = | 174.0 | nM | 6.76 |
| CHEMBL4127125 | — | IC50 | = | 212.0 | nM | 6.67 |
| CHEMBL222813 | ZANAMIVIR | IC50 | = | 257.5 | nM | 6.59 |
| CHEMBL4125754 | — | IC50 | = | 14480.0 | nM | 4.84 |
| CHEMBL4125895 | — | IC50 | = | 32230.0 | nM | 4.49 |