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Assay Detail

CHEMBL4121161

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of EGFP-fused MERS-CoV spike protein mediated cell-cell fusion between viral protein expressing human 293T cells and human HuH7 target cells after 4 hrs by inverted fluorescence microscopic analysis
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Middle East respiratory syndrome-related coronavirus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Discovery of Hydrocarbon-Stapled Short α-Helical Peptides as Promising Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Fusion Inhibitors.
Wang C, Xia S, Zhang P, Zhang T, Wang W, Tian Y, Meng G, Jiang S, Liu K.
J Med Chem (2018) 61 : 2018 -2026
PubMed 29442512 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 22 5.42 6.58

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4130273 1 6.58
CHEMBL4126311 1 6.48
CHEMBL4127619 1 6.20
CHEMBL4127413 1 6.12
CHEMBL4126244 1 5.67
CHEMBL4126397 1 5.45
CHEMBL4125813 1 5.41
CHEMBL4129150 1 5.41
CHEMBL4127482 1 5.35
CHEMBL4127810 1 5.15
CHEMBL4128871 1 5.09
CHEMBL4129211 1 4.97
CHEMBL4127688 1 4.96
CHEMBL4128721 1 4.96
CHEMBL4127000 1 4.85
CHEMBL4129684 1 4.79
CHEMBL4130088 1 4.69
CHEMBL4125767 1 -
CHEMBL4129054 1 -
CHEMBL4129107 1 -
CHEMBL4127750 1 -
CHEMBL4129889 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4130273 EC50 = 260.0 nM 6.58
CHEMBL4126311 EC50 = 330.0 nM 6.48
CHEMBL4127619 EC50 = 630.0 nM 6.20
CHEMBL4127413 EC50 = 750.0 nM 6.12
CHEMBL4126244 EC50 = 2160.0 nM 5.67
CHEMBL4126397 EC50 = 3550.0 nM 5.45
CHEMBL4125813 EC50 = 3900.0 nM 5.41
CHEMBL4129150 EC50 = 3890.0 nM 5.41
CHEMBL4127482 EC50 = 4490.0 nM 5.35
CHEMBL4127810 EC50 = 7140.0 nM 5.15
CHEMBL4128871 EC50 = 8210.0 nM 5.09
CHEMBL4129211 EC50 = 10700.0 nM 4.97
CHEMBL4127688 EC50 = 10900.0 nM 4.96
CHEMBL4128721 EC50 = 10900.0 nM 4.96
CHEMBL4127000 EC50 = 14100.0 nM 4.85
CHEMBL4129684 EC50 = 16300.0 nM 4.79
CHEMBL4130088 EC50 = 20600.0 nM 4.69
CHEMBL4125767 EC50 > 50000.0 nM -
CHEMBL4129054 EC50 > 50000.0 nM -
CHEMBL4129107 EC50 > 50000.0 nM -
CHEMBL4127750 EC50 > 50000.0 nM -
CHEMBL4129889 EC50 > 50000.0 nM -